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Wife and antidepressants

My wife has been on 20mg of prozac daily for about 15 years. She suffered from depression in her teenage years. I feel like it's time that she thinks about either weaning herself off of them or changing types. Of course the side affect are horrible, no libido, weight gain ect. Lately he has been doing a lot of work on herself, as far as exercising and trying to get in shape. She always complains that she has a hard time losing the weight. In my opinion it it partely due to the Prozac. I know that when I talk to her about it she will think that all its just because I want to have sex with her more often. That's true but I want her to lose the weight. She suffers from low self esteem and losing the weight is a good way to boost that. What do you all think the best way for me to approach this subject is, as I will probably be met with resistance from her?

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